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GABARAP (Gamma-aminobutyric Acid Receptor-associated Protein, GABA(A) Receptor-associated Protein, MM46, FLC3B, HT004)

GABARAP (Gamma-aminobutyric Acid Receptor-associated Protein, GABA(A) Receptor-associated Protein, MM46, FLC3B, HT004)

Cat no: G1015-24G

Supplier: United States Biological
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GABARAP, a 17kD microtubule-associated polypeptide, is a novel member of a MAP-protein family which participate in intracellular membrane trafficking. It consists of a basic aa rich N-terminus, GABA (A) receptor interaction domain and a putative tubulin-binding motif. Localized in the intracellular membranes, GABARAP binds to gamma-2 subunit of GABA (A) receptors and plays a vital role GABA (A) receptor clustering and trafficking to the plasma membrane in neurons. It interacts with various proteins like Gephyrin, tubulin, NSF and transferin receptor and mediates efficient neuronal communication. Role of GABARAP has been implicated as a tumor suppressor in breast cancer. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G1015-24G
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Wang H. et. al. Nature (1999) 397: 69-72 2. Wang H et.al J Neurochem., 75(2):644-55 (2000 Aug) 3. L Chen et.al PNAS 97 (21); 11557-11562 (October 10, 2000) 4. VN Bavro et.al EMBO Reports 3 (2); 183-189 (2002) 5. JE Coyle The Neuroscientist, 9 (3), 205-216 (2003) 6. TA Leil et.al J. Neurosci., 24(50): 11429
Additional info: Recognizes human GABARAP. Species Crossreactivity: mouse and rat.

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