GalR2 is a Galanin Receptor that is involved in neuroendocrine regulation and control of feeding behavior. In contrast to GalR1, the primary signaling mechanism of GalR2 is through phospholipase C/protein kinase C. GalR2 expression has been documented widely in the brain and in peripheral tissues including small intestine, heart, kidney, and liver. Localization data from rat CNS indicate high levels of expression in dorsal root ganglia, amygdala, Purkinje neurons, dentate gyrus, hypothalamus, pituitary, and cingulate, entorhinal, and piriform cortices, among others. Conflicting expression results have been documented in the literature with respect to the CNS and peripheral expression patterns. ESTs have been isolated from mouse brain libraries.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 40ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Human Brain, Neurons and glia
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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