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Gastric Inhibitory Polypeptide Receptor (GIPR, GIP-R, Glucose-dependent Insulinotropic Polypeptide Receptor)

Cat no: G2019-30C

Gastric Inhibitory Polypeptide Receptor (GIPR, GIP-R, Glucose-dependent Insulinotropic Polypeptide Receptor)

Gastric inhibitory polypeptide, also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIPR. Together with glucagon-like peptide-1, GIPR is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.\n\nApplications:\nSuitable for use in Western Blot, Immunocytochemistry, Flow cytometry and Immunohistochemistry. Other applications have not been tested. \n\nRecommended Dilutions: \nWestern Blot: 1:1000-1:10,000 \nImmunohistochemistry: 1:50-1:100 \nImmunocytochemistry: 1:50-1:100\nFlow cytometry: 1:10-1:100\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.\n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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SPECIFICATIONS

Catalog Number

G2019-30C

Size

100ul

Applications

FC, ICC, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.

P Type

Mab

Purity

Supernatant

Additional Info

Recognizes human Gastric Inhibitory Polypeptide Receptor. Species crossreactivity: Mouse, rat.

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