Home  >  Products  >  GGCX (Gamma-glutamyl Carboxylase, GC, FLJ26629, Vitamin K-dependent gamma-carboxylase, Vitamin K gamma Glutamyl Carboxylase, VKCFD1)
GGCX (Gamma-glutamyl Carboxylase, GC, FLJ26629, Vitamin K-dependent gamma-carboxylase, Vitamin K gamma Glutamyl Carboxylase, VKCFD1)

GGCX (Gamma-glutamyl Carboxylase, GC, FLJ26629, Vitamin K-dependent gamma-carboxylase, Vitamin K gamma Glutamyl Carboxylase, VKCFD1)

Cat no: G2033-63

Supplier: United States Biological
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This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Western Blot: 0.3-1ug/ml detects ~85kD band observed in Human Muscle lysates (calculated MW of 85kD according to NP_000812.2). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2033-63
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: vitamin K-dependent gamma-carboxylase, VKCFD1, FLJ26629, gamma-glutamyl carboxylase, GGCX
References: 1. Li Q, Grange DK, Armstrong NL, Whelan AJ, Hurley MY, Rishavy MA, Hallgren KW, Berkner KL, Schurgers LJ, Jiang Q, Uitto J, Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes. J Invest Dermatol. 2009 Mar;129(3):553-63. Epub 2008 Sep 18.
Additional info: Recognizes human GGCX. Species sequence homology: canine. Expected to recognize both isoforms (NP_000812.2; NP_001135741.1).

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