Giantin (Recombinant) (Golgin Subfamily B Member 1, 372 D Golgi Complex-associated Protein, GCP372, Macrogolgin)

Giantin, the largest Golgi membrane protein, is C-terminally anchored to cis- and medial-Golgi membranes and forms a long ~250nm coiled-coil rod that directly interacts with microtubules in a cell-cycle regulated way. It is an excellent marker for mammalian golgi complex. It is also an antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.\n\nApplications:\nSuitable for use in Immunocytochemistry. Other applications not tested.\n\nRecommended Dilutions:\nImmunocytochemistry: 1:1000\nOptimal dilutions to be determined by researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

044839

Size

100ug

Applications

ICC

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.02% sodium azide, 10% glycerol

P Type

Mab

Purity

Purified

Isotype

IgG2

References

1. Recombinant antibodies selected against subcellular fractions to track endogenous protein dynamics in vivo: C. Nizak, et al.; Traffic 7, 739 (2003) 2. Characterization of single chain antibody targets through yeast two hybrid: O. Vielemeyer, et al; BMC Biotechnol. 10, 59 (2010).

Additional Info

Recognizes human giantin. Species Crossreactivity: mouse

Alternative Names

Golgin Subfamily B Member 1, 372 kDa Golgi Complex-associated Protein, GCP372, Macrogolgin