GITRL (Glucocorticoid Induced TNF-Related Ligand, AITRL, Activation-Inducible TNF-Related Ligand, TNFSF18) (PerCP)

Tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamily members are regulators of diverse cellular functions such as proliferation, differentiation, and survival/apoptosis. The glucocorticoid-induced TNFR family-related protein (GITR, also known as TNFRSF18 and AITR) is an inducible type I transmembrane protein that modulates T cell survival. The ligand for GITR\n(GITR Ligand/TNFSF18, also known as AITRL or TL6) is a type II transmembrane protein expressed on endothelial cells, dendritic cells, retinal pigment epithelium and photoreceptor inner segments of the eye, and on stimulated monocytes. Stimulation by LPS and viral infection leads to enhanced expression of GITR Ligand on endothelial cells and antigen presenting cells. Interactions between GITR and GITR Ligand are believed to play a significant role in immunologic tolerance, and immune cell function in the periphery.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nMyeloma cells with B cells from Balb/c mice. \n\nAbsorption: 482nm-564nm\n\nEmission: 675nm\n\nStorage and Stability:\nMay be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. PerCP conjugates are sensitive to light.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts