May play a role in regulating the function of the thioredoxin system. Interacts weakly with PKC-theta. Protein is cytoplasmic; under the plasma membrane. After PMA stimulation, TXNL2/PICOT and PRKCQ/PKC-theta translocate to a more extended submembrane area. Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine. The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.
Source:
Recombinant protein corresponding to TXNL2, fused to His-tag at N-terminal expressed in E.coli.
Molecular Weight:
~38.5kD
Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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