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GluR1 (Glutamate Receptor 1, GluR-1, AMPA-selective Glutamate Receptor 1, GLUH1, GLURA, GluR-A, GluR-K1, Glutamate Receptor Ionotropic AMPA 1, GluA1, GRIA1, HBGR1, MGC133252)

Cat no: G3500-03D

GluR1 (Glutamate Receptor 1, GluR-1, AMPA-selective Glutamate Receptor 1, GLUH1, GLURA, GluR-A, GluR-K1, Glutamate Receptor Ionotropic AMPA 1, GluA1, GRIA1, HBGR1, MGC133252)

Glutamate receptors (GluRs) are the most important mediators of excitatory signal transduction in the central nervous system. They can be pharmacologically classified in three distinct classes: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, kainate (KA) receptors, and N-methyl-D-aspartate (NMDA) receptors. The AMPA-type glutamate receptor opens in response to glutamate binding, and mediates most of the rapid excitatory postsynaptic current. The activation of AMPA receptors leads to stimulation of a multitude of biochemical pathways in postsynaptic neurones eventually leading to postsynaptic neuronal plasticity. GluR1 belongs to the family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. GluR1 gene is located on human chromosome 5q33 and is expressed granule and pyramidal cells in the hippocampal formation.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:500-1:1000\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMouse brain tissue\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G3500-03D

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Lei, S, et al. The Journal of Neuroscience. 20:7932-7940 (2000). 2. Nathalie, S. et al. The Journal of Physiology. 565:381-390 (2005).

Additional Info

Recognizes human GluR1. Species Crossreactivity: mouse and rat.

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