GluR1 (Phospho-Ser845) Polyclonal Antibody

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser845 of GluR1 . Host: rabbit . Cross Reactivity: (+) rat GluR1 . Application(s): IHC and WB . The AMPAR are comprised of four distinct GluR subunits designated (GluR1-4), which play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is potentiated by phosphorylation at Ser845 which has been shown to be mediated by either PKC or CaM kinase II. Phosphorylation of this site has also been linked to synaptic plasticity as well as learning and memory.

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SPECIFICATIONS

Catalog Number

10601

Applications

IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser845 of GluR1

Storage Temp

-20

Shipping Temp

-20

Additional Info

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by (alpha)-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser845 which has been shown to be mediated by either PKC or CaM kinase II. In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory.