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Glutamate receptor 5/1 (metabotropic)

Glutamate receptor 5/1 (metabotropic)

Cat no: G3500-31

Supplier: United States Biological
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Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainate receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors, stimulate phospholipase C as revealed by an increase in phosphoinositide turnover, and Ca2+ release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3. Applications: Suitable for use in Western Blot and Immunohistochemistry (Fr). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G3500-31
Reactivities: Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ul
Form: Tris- glycine
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Pin, j-P, Duvoisin, R. Review: Neurotransmitter receptor 1: The metabotropic glutamate receptors: structure and function. Neuropharmacology. 34: 1-26, 1995.
Additional info: Specific for metabotropic glutamate receptor 5 (mGluR5/1). This antibody crossreacts with mGluR1a. Species Crossreactivity: reacts with rat mGluR5/1. Other species have not been tested, but should work with most mammalian species due to sequence homology.

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