Glycogen Synthase Kinase 3 alpha, beta, phosphorylated (Ser21/9) (GSK3a/b, GSK-3 alpha/beta)

Cat no: G8170-43B1

Supplier: United States Biological

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GSK-3 is a serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 has been implicated in the regulation of cell fate and in the Wnt signaling pathway. GSK-3 plays an important role in the PI3 kinase and Akt mediated cell survival pathways, and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3a and Ser9 of GSK-3b. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Immunohistochemistry: 20-30ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	G8170-43B1
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug
Form:	Supplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% sodium azide, 50% glycerol.
P type:	Pab
Isotype:	IgG
Purity:	Purified by immunoaffinity chromatography.
Additional info:	Recognizes human GSK-3 only when phosphorylated at Ser21 of GSK-3a or Ser9 of GSK-3b. Species Crossreactivity: Mouse and rat.

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Glycogen Synthase Kinase 3 alpha, beta, phosphorylated (Ser21/9) (GSK3a/b, GSK-3 alpha/beta)

Cat no: G8170-43B1

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