Glycophorin C (Glycophorin-C, Glycoconnectin, Glycophorin-D, GPD, Glycoprotein beta, PAS-2', Sialoglycoprotein D, CD236, GYPC, GLPC, GPC)

Four main species of sialic acid-rich glycoproteins known as glycophorins A, B, C, and D have been characterized on human erythrocytes. These components carry blood group determinants and various receptors for lectins, bacteria, viruses, and parasites. Glycophorin C (GPC) is the minor constituent carrying the Gerbich blood group antigens which plays significant role in the maintenance of erythrocyte shape by regulating the deformability and mechanical stability of red cells. The protein is a single polypeptide chain of 128aa spanning the phospholipid bilayer. The gene encoding for glycophorin C is mapped on 2q14-q21 region of human chromosome organized in four exons over 13.5kb pair DNA and contains two internal direct repeated domains of 3.4kb which are likely to derive from a recent duplication. Glycophorin C has very little homology with glycophorin A and B.\n\nApplications: \nSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry: frozen \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2548-98L3

Size

200ug

Applications

IHC, IP, WB

Hosts

Mouse

Form

Supplied as a liquid in Tris buffered glycine, pH7.5, 0.09% sodium azide.

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1. King, M.J. et al. (1995). Reactivity with erythroid and non-erythroid tissues of a murine monoclonal antibody to a synthetic peptide having amino acid sequence common to cytoplasmic domain of human glycophorins C and D. Brit. J. Haematol. 89:440-448.

Additional Info

Recognizes human CD236a.

Alternative Names

Glycophorin C (Gerbich Blood Group)