GNPDA1 (Glucosamine-6-phosphate Deaminase 1, Glucosamine-6-phosphate Isomerase 1, GlcN6P Deaminase 1, Oscillin, GNPI, HLN, KIAA0060)

GNPDA1 is an allosteric enzyme catalyzing the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium, a reaction that under physiological conditions proceeds to the formation of fructose-6-phosphate. It is the sole enzyme linking hexosamine systems with glycolytic pathways by transferring hexosamines from structural macromolecules into the glycolytic pathway. GNPDA1 localizes close to the developing acrosome vesicle and in spermatozoa close to the acrosomal region, and may play a role in the acrosome reaction. Human GNPDA1 gene is localized to chromosome 5q21.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5-1ug/ml\nImmunohistochemistry (formalin fixed paraffin embedded): 10ug/ml\nOptimal dilutions to be determined by the researcher. \n\nPositive Control:\nHuman, mouse and rat spleen lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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