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Products GPR120 (C-Term) Polyclonal Antibody
| Catalogue number: | 14265 |
| Hosts: | Rabbit |
| Applications: | ELISA, Immunocytochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human GPR120 amino acids 364-375 |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | G Protein-Coupled Receptor (GPR120) is a GPCR activated by the presence of long chain free fatty acids and is expressed in adipocytes and pro-inflammatory macrophages. The activation of GPR120 results in elevated Ca2+ and activation of the ERK cascade. ?-3 Fatty acid constituents such as DHA and EPA mediate GPR120 signaling resulting in inhibition of TLR and TNF-(alpha) inflammatory signaling pathways in a (beta)-arrestin2/TAB1 dependent manner. The anti-inflammatory effects of GPR120 are indirectly involved in promoting insulin secretion and free fatty acid-induced inhibition of apoptosis. The predicted size for GPR120 is 42.2 kDa and the observed detection is approximately 43 kDa by Western blot. |
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