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GPR120 (C-Term) Polyclonal Antibody

Cat no: 14265

GPR120 (C-Term) Polyclonal Antibody

Antigen: human GPR120 amino acids 364-375 . Host: rabbit . Cross Reactivity: (+) human GPR120 . Application(s): ELISA, ICC, and WB

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SPECIFICATIONS

Catalog Number

14265

Applications

ELISA, ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human GPR120 amino acids 364-375

Storage Temp

-20

Shipping Temp

-20

Additional Info

G Protein-Coupled Receptor (GPR120) is a GPCR activated by the presence of long chain free fatty acids and is expressed in adipocytes and pro-inflammatory macrophages. The activation of GPR120 results in elevated Ca2+ and activation of the ERK cascade. ?-3 Fatty acid constituents such as DHA and EPA mediate GPR120 signaling resulting in inhibition of TLR and TNF-(alpha) inflammatory signaling pathways in a (beta)-arrestin2/TAB1 dependent manner. The anti-inflammatory effects of GPR120 are indirectly involved in promoting insulin secretion and free fatty acid-induced inhibition of apoptosis. The predicted size for GPR120 is 42.2 kDa and the observed detection is approximately 43 kDa by Western blot.

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