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Products GPR17 (C-Term) Polyclonal Antibody
| Catalogue number: | 10136 |
| Hosts: | Rabbit |
| Applications: | Flow Cytometry, Immunocytochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human GPR17 amino acids 351-367 (SFEGKTNESSLSAKSEL) |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | GPR17 is a G protein-coupled receptor that has been identified as a dualistic receptor recognizing signals from two unrelated chemical families: nucleotides and CysLTs. The deorphanization of GPR17 supports the suggested crosstalk between nucleotides and CysLTs during inflammation and injury. mRNA transcripts encoding this transmembrane receptor are most strongly expressed in the brain, kidney, and heart. Upon ischemic injury, GPR17 is upregulated in these tissues and its inhibition has been shown to decrease ischemic damage. This finding suggests GPR17 as a pharmacological target of ischemic injury. Cayman |
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