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Products GPR40 Polyclonal Antibody
| Catalogue number: | 10007205 |
| Hosts: | Rabbit |
| Applications: | Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human GPR40 amino acids 210-222 |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | GPR40 is a seven transmembrane G Protein-coupled receptor with signalling mediated by medium- and long-chain fatty acids. Found predominantly in the .beta.-cells of pancreatic islets, it has been implicated in the regulation of insulin secretion. Overexpression of GPR40 in mouse .beta. cells leads to glucose intolerance suggesting a link between GPR40 expression and diabetes. The receptor has also been identified as a possible mediator of oleate- and linoleate- stimulated proliferation of the human breast cancer cell line, MCF-7. GPR40 has a calculated mass of 31.4 kDa bases on its amino acid sequence. |
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