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GPR43 (Internal) Polyclonal Antibody

Cat no: 15727

GPR43 (Internal) Polyclonal Antibody

Antigen: peptide from the internal region of human GPR43 . Host: rabbit . Cross Reactivity: (+) human GPR43 . Application(s): FC, IF, and WB

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SPECIFICATIONS

Catalog Number

15727

Applications

FC, IF, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Fatty Acid Binding Proteins|Intracellular Signaling|Lipid Mediators

Weight

0

Antigen

peptide from the internal region of human GPR43

Storage Temp

-20

Shipping Temp

-20

Additional Info

GPR43 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). Several SCFAs have the potential to bind and activate GPR43, including acetate, formate, propionate, and butyrate. GPR43 couples through the Pertussis toxin-sensitive Gi/o and the pertussis toxin-insensitive Gq protein families and its expression has been described in enteroendocrine cells and neutrophils. The activation of GPR43 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP. Activation of GPR43 may be involved in intestinal inflammation. The predicted size of GPR43 is 37 kDa. Cayman

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