GPR55 Polyclonal Antibody

Antigen: human GPR55 amino acids 207-219 . Host: rabbit . Cross Reactivity: (+) human, bovine, and mouse (Neuro-2a cells) GPR55 . Application(s): FC, ICC, and WB . GPR55 is a GPCR identified as a novel cannabinoid receptor that binds THC, anandamide, methanandamide, JWH015, and many other cannabinoid ligands. This receptor is widely expressed in the brain, specifically found in large dorsal root ganglion neurons.

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SPECIFICATIONS

Catalog Number

10224

Applications

FC, ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Cannabinoids

Weight

0

Antigen

human GPR55 amino acids 207-219 (ILLGRRDHTQDWV)

Storage Temp

-20

Shipping Temp

-20

Additional Info

GPR55 is a G protein-coupled receptor that has been identified as a novel cannabinoid receptor, although its exact role is still controversial. Previously central cannabinoid (CB1) and peripheral cannabinoid (CB2), two widely characterized receptors have been shown to bind THC the active component of cannabis and other endocannabinoids. Mounting evidence suggests that additional receptors play a role in cannabinoid-related signal transduction and GPR55 has been identified as one of them. This receptor is widely expressed in the brain, specifically found in large dorsal root ganglion neurons. Along with binding THC, it also shows high affinity to anandamide, methanandamide, JWH015, and many other cannabinoid ligands. The human protein shows 75% and 78% overall sequence homology with the rat and mouse proteins, respectively. GPR55 is composed of 319 amino acids and has an expected molecular weight of 37 kDa. Post-translational modifications such as glycosylation may retard receptor electrophoretic migration and thereby protein signal may be detected above 37 kDa.