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GPR91 (Succinate Receptor 1, G-protein Coupled Receptor 91, P2Y Purinoceptor 1-like, SUCNR1)

GPR91 (Succinate Receptor 1, G-protein Coupled Receptor 91, P2Y Purinoceptor 1-like, SUCNR1)

Cat no: G8600-95D

Supplier: United States Biological
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SUCNR1 is a 330aa containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N-terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell communication. SUCNR1 a receptor for the citric acid cycle intermediate succinate, functions in establishing a neovascular network during development and in response to injury. SUCNR1, in response to increased succinate levels, regulates the production of numerous angiogenic factors including VEGF and may be involved in the modulation of platelet function. It is known to play an essential role in proliferative ischemic retinopathy and is an attractive target for treating diseases such as diabetic retinopathy that stem from aberrant neovascularization in the mature retina. Expression of SUCNR1 is common in kidney and in some other tissues. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.25-0.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8600-95D
Reactivities: Human, Mouse, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. He, W. et al. Nature. 429:188-193 (2004). 2. Wittenberger, T. et al. J. Molec. Biol. 307:799-813 (2001).
Additional info: Recognizes human GPR91. Species Crossreactivity: chimpanzee, monkey. Species sequence homology: mouse, rat, canine.

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