GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant mouse GM-CSF is a 14.2kD globular protein consisting of 124aa.
Source:
Recombinant protein corresponding to mouse GM-CSF, expressed in E.coli.
Biological Activity:
Determined by the dose-dependent stimulation of the proliferation of mouse FDC-P1 cells. The ED50 was found to be 0.2ng/ml
Specific Activity:
5x10e6units/mg
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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