Granzyme B Inhibitor Screening BioAssay(TM) Kit (Fluorometric)

Supplier:

United States Biological

Cat no: 167845

Granzyme B Inhibitor Screening BioAssay(TM) Kit (Fluorometric)

Granzyme B (GZMB, EC number 3.4.21.79) also known as Granzyme-2 is a serine protease stored in the granules of activated cytotoxic T cells and NK cells. Upon target cell contact, Granzyme B is directionally exocytosed and with the assistance of perforin enters the target cell. With its unique substrate specificity (Granzyme B prefers an aspartic acid residue at the P1 site of its substrates), Granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. \n\nIntended Use:\nUsed for screening Granzyme B inhibitors, characterize and study Granzyme B inhibitors.\n\nTest Principle:\nIn the Granzyme B Inhibitor Screening BioAssay(TM) Kit, active human Granzyme B enzyme hydrolyzes the specific substrate to release the quench of fluorescent group, which can be detected fluorometrically at Ex/Em = 380/500nm. In the presence of potent Granzyme B Inhibitor, the hydrolyzation of substrate will be impeded. The Kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Granzyme B inhibitors or characterize/study Granzyme B inhibitors. Inhibitor control, Ac-IEPD-CHO is included to compare the efficacy of test inhibitors.\n\nKit Components:\nGranzyme B Assay Buffer, 1x25ml\nGranzyme B Substrate, 1x500ul\nGranzyme B Enzyme, human recombinant, 1x vial\nInhibitor Control, Ac-IEPD-CHO, 250um, 1x20ul\n\nStorage and Stability:\nStore powder at 4 degrees C liquid at -20 degrees C. Store other components at 4 degrees C. Stable for at least 6 months For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

167845

Size

100Tests

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

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