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GroES, aa1-102, Recombinant, Human (Chaperonin 10, cpn10, Heat Shock Protein 10, HSP10)

Cat no: G8976-06B

GroES, aa1-102, Recombinant, Human (Chaperonin 10, cpn10, Heat Shock Protein 10, HSP10)

HSP10, 1-102aa, Human, Recombinant, E. coli\n\nFull name: Heat shock protein 10 \n\nNCBI Accession: NP_002148\n\nSynonyms: Chaperonin 10, CPN10, GroES, \n\nHeat shock protein (HSP) 10 is a member of the highly conserved group of molecular chaperons, which are necessary for efficient folding of many proteins in normal and stress conditions and have been implicated in several human diseases. HSP10 is the ~10kD mammalian equivalent to GroES of E.coli. The function of Hsp10 is to bind Hsp60 (also known as chaperonin-60), in the presence of ATP, thereby promoting a conformational change in Hsp60 and enclosing the protein substrate within the complex. ATP hydrolysis by Hsp60 destabilizes the Hsp60/ Hsp10 complex, allowing it to dissociate and release the substrate protein. \n\nRecombinant human HSP10 was expressed in E. coli and purified by using conventional chromatography techniques.\n\nMolecular Weight: 10kD (102 aa)\n\nSequence: MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG \nSGSKGKGGEI QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY VD\nGeneral references:\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G8976-06B

Size

100ug

Form

Supplied as a liquid in 20mM Tris, pH 8.0, 50mM sodium chloride.

Purity

(same/more than) 98% by SDS PAGE

References

Lin KM., et al. (2004), FASEB J. Jun;18(9):1004-6\nH

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