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GSI-953

Cat no: 012979


Supplier: United States Biological
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Begacestat (GSI-953) is a selective b-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia. Pfizer Compound
Catalogue number: 012979
Size: 10mg
Alternative names: 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide; Begacestat; GSI 953;
References: van Es., et al.: Nature, 435, 959 (2005), Morohashi., et al.: J. Biol. Chem., 281, 1467 (2006), O'Neil., et al.: Neoplasia, 107, 781 (2006), Mayer, et al.: J. Med. Chem., 51, 7348 (2008), Martone, et al.: J. Pharmacol. Exp. Ther., 331, 598 (2009),

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