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GSK2578215A (5-(2-Fluoro-4-pyridinyl)-2-(phenylm ethoxy)-N-3-pyridinylbenzamide)

Cat no: 145675

GSK2578215A (5-(2-Fluoro-4-pyridinyl)-2-(phenylm ethoxy)-N-3-pyridinylbenzamide)

Potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1nm respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Displays selectivity for LRRK2 against a panel of 460 other kinases. Blocks Ser910 and Ser935 phosphorylation in vitro and in peripheral tissues in vivo. Brain penetrant.\n\nFormula:\nC24H18FN3O2\n\nSolubility:\nDMSO (~100mM)\n\nMolecular Weight:\n~399.42\n\nStorage and Stability:\nStore at RT. Stable for 12 months.

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SPECIFICATIONS

Catalog Number

145675

Size

10mg

Form

Supplied as a white solid.

Purity

~99% (HPLC)

References

1. Reith et al (2012) GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substituent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg.Med.Chem.Lett. 22: 625. PMID: 22863203.

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