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GSK3a, NT (Glycogen Synthase Kinase 3 alpha, gsk3a)

GSK3a, NT (Glycogen Synthase Kinase 3 alpha, gsk3a)

Cat no: G8170-42V

Supplier: United States Biological
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Glycogen synthase kinase 3 (GSK3) is implicated in multiple biological processes including metabolism, gene expression, cell fate determination, proliferation, and survival. Two closely related GSK3 isoforms encoded by distinct genes: GSK3a (51kD) and GSK3b (47kD). GSK3 activity is inhibited through phosphorylation of serine 21 in GSK3a and serine 9 in GSK3b. Serine 21 in GSK3a and serine 9 in GSK3b are also physiological substrates of cAMP-dependent protein kinase A. Studies in zebrafish model shows that GSK3a, but not GSK3b, is necessary in cardiomyocyte survival; the GSK3b plays important roles in modulating the left-right asymmetry and affecting heart positioning; and GSK3a and GSK3b play distinct roles during zebrafish cardiogenesis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8170-42V
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Fang, X. et al. Proc. Natl. Acad. Sci. USA 97, 11960 (2000). 2. Lee, HC, Et al.BMC Dev Biol. 3;7:93 (2007).
Additional info: Recognizes zebrafish GSK3a.

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