Gsk3b, NT (Gsk3b, Glycogen synthase kinase-3 beta, Serine/threonine-protein kinase GSK3B) (PE)

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity).\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036332-PE

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Liu, Y., et al. Diabetologia 53(12):2600-2610(2010)\nGraham, J.A., et al. J. Biol. Chem. 285(43):32852-32859(2010)\nAhmad, I., et al. Oncogene (2010) In press :\nAsada, N., et al. J. Neurosci. 30(26):8852-8865(2010)\nCarew, R.M., et al. BMC Dev. Biol. 10, 73 (2010) :

Additional Info

Mouse

Alternative Names

Gsk3b, Glycogen synthase kinase-3 beta, Serine/threonine-protein kinase GSK3B