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Heat Shock Protein 27 (HSP27), phosphorylated (Ser82) BioAssay(TM) ELISA Kit, Human

Cat no: H1830-52J

Heat Shock Protein 27 (HSP27), phosphorylated (Ser82) BioAssay(TM) ELISA Kit, Human

HSP27 (Heat Shock Protein 27; Estrogen regulated 24kD protein) is a member of the ubiquitously expressed anti-apoptotic heat shock protein group with Mr=27 kD. Other members of this group include HSP70 andHSP90. The human gene maps to chromosome 7 (band 7q). Human HSP27 shares 80% homology with the mouse homolog HSP25 and 43% homology with the C. elegans protein C09B8.6. HSP27

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SPECIFICATIONS

Catalog Number

H1830-52J

Size

96Tests

Applications

ELISA

References

1. Charette, S.J., et al. (2000) Inhibition of Daxx-mediated apoptosis by Heat Shock Protein 27. Mol. Cell. Biol. 20(20):7602-7612. 2. Bruey, J.-M., et al. (2000) HSP27 negatively regulates cell death by interacting with cytochrome c. Nature Cell Biol. 2:645-652. 3. Parcellier, A., et al. (2003) HSP27 is a ubiquitin-binding protein involved in I-kappa B alpha proteasomal degradation. Mol. CellBiol. 23(16):5790-5802. 4. Lewis, S.E. (1999) A role for HSP27 in sensory neuron survival. J. Neurosci. 19(20):8945-8953. 5. Korneeva, I., et al. (2002) Cell-free 27 kDa heat shock protein (HSP27) and HSP27-cytochrome c complexes in the cervix of women with ovarian or endometrial cancer. Int. J. Cancer 102(5):483-486. 6. Rane, M. J., et al. (2003) Heat shock protein 27 controls apoptosis by regulating Akt activation. J. Biol. Chem. In press. 7. Konishi, H., et al. (1997) Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein HSP27. FEBS Lett. 410:493-498. 8. Rogalla, T., et al. (1999) Regulation of HSP27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor a by phosphorylation. J. Biol. Chem. 274:18947-18956. 9. Spector, N.L. et al. (1993) Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells. J. Cell Physiol. 156:619-625.

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