Heat Shock Protein 70 Interacting Protein, Recombinant, Human (Heat Shock Protein Binding Protein 1, Hsp70 Binding Protein 1, HSPBP1, HSPBP, FES1, Hsp70 Binding Protein 2, HspBP2, Hsp70-interacting Protein 1, Hsp70-interacting Protein 2, PP1845)

Hsp70-binding protein 1, also known as HSPBP1, belongs to a family of eukaryotic proteins identified as nucleotide exchange factors for HSP 70, which exhibit varying degrees of compartment and species specificity. It is localized primarily in cytoplasm and nucleus but is also found extracellularly. HspBP1 binds to HSP 70, inhibits its activity and promotes dissociation of nucleotides from the HSP 70 ATPase domain. It is mainly expressed in heart and skeletal muscle. Recombinant human HSPBP1, fused to His-tag at N-terminus, was expressed in E. coli.\n\nSource: \nRecombinant corresponding to aa1-362 of human HSPBP1 6x His tagged expressed in E. coli.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MSDEGSRGSR LPLALPPASQ GCSSGGGGGG GGGSSAGGSG NSRPPRNLQG LLQMAITAGS EEPDPPPEPM SEERRQWLQE AMSAAFRGQR EEVEQMKSCL RVLSQPMPPT AGEAEQAADQ QEREGALELL ADLCENMDNA ADFCQLSGMH LLVGRYLEAG\nAAGLRWRAAQ LIGTCSQNVA AIQEQVLGLG ALRKLLRLLD RDACDTVRVK ALFAISCLVR EQEAGLLQFL RLDGFSVLMR AMQQQVQKLK VKSAFLLQNL LVGHPEHKGT LCSMGMVQQL VALVRTEHSP FHEHVLGALC SLVTDFPQGV RECREPELGL EELLRHRCQL LQQHEEYQEE\nLEFCEKLLQT CFSSPADDSM DR\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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