Heat Shock Protein 90 alpha, Recombinant, Human (HSP90a)

Supplier:

United States Biological

Cat no: H1832-85A

Heat Shock Protein 90 alpha, Recombinant, Human (HSP90a)

The 90kD molecular chaperone family comprises several proteins including the 90kD heat shock protein, Hsp90 and the 94kD glucose-regulated protein, grp94 which are major molecular chaperones of the cytosol and of the endoplasmic reticulum. In mammalian cells there are at least two Hsp90 isoforms, Hsp90alpha and Hsp90beta which are encoded by separate genes. The amino acid sequence of human and yeast Hsp90alpha is 85% and 90% homologous to that of Hsp90beta respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions which have been shown to contain independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cell

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SPECIFICATIONS

Catalog Number

H1832-85A

Size

200ug

Form

Supplied as a liquid in 45mM Tris-HCl, pH 8.0, 124mM sodium chloride, 2.4mM potassium chloride, 225mM imidazole, 3mM DTT, 10% glycerol.

Purity

~60%

References

1. Wayne N. and Bolon D.N. J Biol Chem. 2007 Nov 30;282(48):35386-95. 2. Pearl L.H., Prodromou C. and Workman P. Biochem J. 2008 Mar 15;410(3):439-53.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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