Hepatitis A Virus Cellular Receptor 2 (HAVCR2, Kidney Injury Molecule 3, KIM3, T cell Immunoglobulin and Mucin Domain Containing 3, TIMD3, T cell Immunoglobulin Mucin 3, TIM3)

CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications have not been tested. \n\nRecommended Dilutions: \nPeptide ELISA Titer: 1:32,000\nWestern Blot: 0.3-1ug/ml ~35kD band observed in Human Tonsil, Thymus, Lymph Node and Spleen lysates (calculated MW of 33.4kD according to NP_116171.3). In transfected HEK293 transiently expressing HAVCR2 a band of ~35kD is observed. This band is not observed in the non-transfected HEK293.\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H1900-34A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by peptide affinity chromatography.

Isotype

IgG

References

1.Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med. 2005 Aug;11(8):362-9. Review. PMID: 16002337

Additional Info

Recognizes human HAVCR2. Species sequence homology: canine.

Alternative Names

kidney injury molecule-3, T cell immunoglobulin mucin-3, T cell immunoglobulin mucin 3, Tim-3, TIMD3, KIM-3, FLJ14428, hepatitis A virus cellular receptor 2, TIM3, HAVCR2