Hepatitis B Surface Antigen, Recombinant (HBsAg)

The HBsAg is produced by genetically engineered CHO cells. The antigen contains the preS2 region of strain adw.\n\nThe hepatitis B virus is an important cause of acute and chronic liver disease. It is also the most common form of parenterally transmitted viral hepatitis. The virus is estimated to affect some 350 million people worldwide. Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries.\n\nHepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus. In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas. There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H1909-08Z3

Size

50ug

Form

Supplied as a liquid in 10mM Tris-HCl, pH 7.5.\n

Purity

(same/more than) 95% pure by column chromatography and CsCl density sedimentation.

References

1. The hepatitis B virus. P. Tiollais et al., Nature 317, 489 (1985). 2. Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized BSA. Mitchell et al. Proc. Natl. Acad. Sci. USA 81, 7708 (1984).