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Herbimycin C (Antibiotic TAN 420D)

Cat no: H2030-35C

Herbimycin C (Antibiotic TAN 420D)

Herbimycin C is a minor analogue of herbimycin complex isolated from Streptomyces hygroscopicus. Herbimycin C possesses potent antitumor activity and has been shown to convert Rous sarcoma virus-infected rat kidney cells into normal cells. Until now limited access has restricted a full investigation of the properties of herbimycin C. Research on related metabolites, herbimycin A and geldanamycin has stimulated intensive interest in this class as selective antitumor agents and for prolonging the viability of tissue-cultured cells and organs.\n\nSoluble in ethanol, methanol, DMF or DMSO. Limited water solubility

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SPECIFICATIONS

Catalog Number

H2030-35C

Size

500ug

Form

Yellow solid

Purity

> 98% by HPLC

References

1. The structure and cytocidal activity of herbimycin C. Shibata K. et al. J. Antibiot. 1986, 39, 1630. 2. Natural product origins of Hsp90 inhibitors. Uehara Y. Curr. Cancer Drug Targets 2003, 3, 325. 3. Inducement of thermotolerance with benzoquinonoid ansamycins. Welch W.J. 2000 US Patent 6015659.

Alternative Names

Antibiotic TAN 420D

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