HES7, Recombinant, Human, aa1-230, His-Tag (Transcription Factor HES-7, Hairy and Enhancer of Split 7, bHLHb37, SCDO4)

Supplier:

United States Biological

Cat no: 138664

HES7, Recombinant, Human, aa1-230, His-Tag (Transcription Factor HES-7, Hairy and Enhancer of Split 7, bHLHb37, SCDO4)

HES7 is a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene. \n\nSource:\nRecombinant protein corresponding to aa1-230 from human HES7 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~27kD (253aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSMVTRDRA ENRDGPKMLK PLVEKRRRDR INRSLEELRL LLLERTRDQN LRNPKLEKAE ILEFAVGYLR ERSRVEPPAA AAPGVPRSPV QDAEALASCY LSGFRECLLR LAAFAHDASP AARAQLFSAL HGYLRPKPPR PKPVDPRPPA PRPSLDPAAP ALGPALHQRP PVHQGHPSPR CAWSPSLCSP RAGDSGAPAP LTGLLPPPPP PHRQDGAPKA PLPPPPAFWR PWP\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138664

Size

100ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.

Purity

~85% (SDS-PAGE)

References

1. Sparrow DB, et al. (2008). Hum Mol Genet. 1;17(23):3761-6. 2. Sillence D, et al. (2010). Eur J Hum Genet. 18(6):674-9.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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