HIF-1(alpha) (C-Term) Polyclonal Antibody

Antigen: HIF-1(alpha) C-terminal amino acids 809-826 . Host: rabbit . Cross Reactivity: (+) human, mouse, and simian HIF-1(alpha) . Application(s): (+) WB; (-) ICC and IP . HIF-1(alpha) is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1(alpha) migrates to the nucleus where, with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival.

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SPECIFICATIONS

Catalog Number

10006421

Applications

ICC, IP, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Intracellular Signaling

Weight

0

Antigen

HIF-1.alpha. amino acids 809-826

Storage Temp

-20

Shipping Temp

-20

Additional Info

Hypoxia inducible factor-1.alpha. (HIF-1.alpha.) is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1.alpha. migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival. HIF-1.alpha. is an endothelial PAS domain protein 1 (EPAS-1) family member with phosphorylation dependent activities. Cayman Chemical's HIF-1.alpha. polyclonal antibody can be used for WB analysis for HIF-1.alpha. on samples from human, mouse, and simian. It is not suitable for ICC or IP. Other applications for use of this antibody have not yet been tested.