HMGB1 Monoclonal Antibody (Clone IMG19N10B7)

Antigen: full length recombinant human HMGB1 . Host: mouse, clone IMG19N10B7 . Isotype: IgG2b? . Cross Reactivity: (+) human and mouse HMGB1 . Applications: FC, IHC (paraffin-embedded tissue), and WB . HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).

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SPECIFICATIONS

Catalog Number

11512

Applications

FC, IHC, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies|Nuclear Receptors|Intracellular Signaling

Weight

0

Antigen

full length recombinant human HMGB1

Isotype

IgG2bk

Storage Temp

-20

Shipping Temp

-20

Additional Info

High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.