

Supplier:
Cayman Chemical CompanyCat no: 11515
HMGB1 Polyclonal Antibody (aa 100-150)
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SPECIFICATIONS
Catalog Number
11515
Applications
FC, IHC, WB
Hosts
Rabbit
Form
1 ea
P Type
Antibodies|Intracellular Signaling
Weight
0
Antigen
human HMGB1 amino acids 100-150
Storage Temp
-20
Shipping Temp
-20
Additional Info
High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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