HOXA9 (Homeobox Protein Hox-A9, Homeobox Protein Hox-1G, HOX1G)

Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes like cell identity, cell division and differentiation. The HOXA9 gene encodes a class I homeodomain protein which is involved in hematopoesis and myeloid differentiation. It shows different splice variants like a 1.8-kb homeobox-containing transcript in fetal brain, lung, liver, and kidney, and 2.2- and 3.3-kb transcripts in fetal and adult kidney and in adult skeletal muscle. Fusion between the HOXA9 gene and the nucleoporin gene NUP98, a member of the GLFG nucleoporin family, on 11p15 occurs as a consequence of leukemia-associated chromosomal translocations. So NUP98-HOXA9 is associated with the t(7;11)(p15;p15) translocation in acute myeloid leukemia, myelodysplastic syndrome, and blastic crisis of chronic myeloid leukemia.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-3ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nKidney\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H7022-90

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Ch/Bird, Fel

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

1. Moore, MA. et al. Annals of New York Academy of Science. 1106:114-142 (2007). 2. Popovic, R. et al. Blood Cells Molecules and Diseases. 40:156-159 (2008). 3. Cantile, M. et al. Nutrition Metabolism and Cardiovascular diseases. 18:651-658 (2008).

Additional Info

Recognizes human Homeobox protein A9/HOXA9. Species Crossreactivity: chicken, feline, mouse, rat, rhesus monkey. Species sequence homology: xenopus, zebrafish.