HSPB2 (Heat Shock Protein beta-2, HspB2, MKBP, 27kD Heat Shock Protein 2, DMPK-binding Protein, MKBP, MGC133245)

HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30% sequence identity to all other mammalian sHSPS (1). MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique nature compared to other sHSps, in that the expression of MKBP is not induced by heat shock (2). In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction (1, 3). During stress, these complexes dissolve and MKBP

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SPECIFICATIONS

Catalog Number

136796

Size

25ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Affinity Purified

References

1. Pinz I., et al. (2008) FASEB J. 22: 84-92. 2. Suzuki A., et al. (1998) J Cell Bio. 140(5): 1113-1124. 3. Sugiyama Y., et al. (2000) J Biol Chem. 275: 1095-1104. 4. Oshita S.E., et al. (2010) Breast Cancer Res Treat. Epub: 20087649.

Additional Info

Recognizes HSPB2 at ~27kD. Species Crossreactivity: Human, mouse and rat.

Alternative Names

Heat Shock Protein beta-2, HspB2, MKBP, 27kD Heat Shock Protein 2, DMPK-binding Protein, MKBP, MGC133245