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Human 14-3-3 protein sigma (SFN) ELISA Kit

Human 14-3-3 protein sigma (SFN) ELISA Kit

Cat no: KTE60683

Supplier: Abbkine Scientific Co.Ltd.
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Stratifin, was shown to be diffusely distributed in the cytoplasm and was present in cultured epithelial cells. It was most abundant in tissues enriched in stratified keratinizing epithelium.The induction of 14-3-3-sigma is mediated by a p53 -responsive element located 1.8 kb upstream of its transcription start site. Exogenous introduction of 14-3-3-sigma into cycling cells results in a G2 arrest. After DNA damage, these cells initially arrested in the G2 phase of the cell cycle, but unlike cells containing 14-3-3-sigma, the 14-3-3-sigma -/- cells were unable to maintain cell cycle arrest. The 14-3-3-sigma -/- cells died (mitotic catastrophe) as they entered mitosis. This process was associated with a failure of the 14-3-3-sigma-deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus.
Catalogue number: KTE60683
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: P31947
Gene: 2810
Additional info: Human 14-3-3 protein sigma (SFN) ELISA Kit has high sensitivity and excellent specificity for detection of Human SFN. No significant cross-reactivity or interference between Human SFN and analogues was observed.

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