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Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) ELISA Kit

Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) ELISA Kit

Cat no: KTE60356

Supplier: Abbkine Scientific Co.Ltd.
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SRD5a2 encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). Steroid 5-alpha-reductase catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT).The cDNA contains a long 3-prime untranslated region and encodes a hydrophobic 254-amino acid protein that shares 50% sequence identity with human SRD5A1 and 46% identity with rat 5-alpha-reductase. The biochemical and pharmacologic properties of the enzyme were consistent with its being the major isozyme in genital tissue.
Catalogue number: KTE60356
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: P31213
Gene: 6716
Additional info: Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) ELISA Kit has high sensitivity and excellent specificity for detection of Human SRD5A2. No significant cross-reactivity or interference between Human SRD5A2 and analogues was observed.

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