Alpha-1-acid glycoprotein (AGP) or orosomucoid is an acute-phase plasma glycoprotein. It is synthesized in the liver and secreted into the plasma. The protein is a single polypeptide chain of 183 amino acids containing high carbohydrate content (45%) of its 41 kDa molecular weight (1). As a consequence of acute infections or inflammation, the plasma concentration of AGP increases considerably. The elevated serum level of AGP is associated with an increased risk of cardiovascular disease. Urinary AGP excretion rate predicts cardiovascular mortality in patients with Type II diabetes (2). AGP can be used as a marker for acute inflammation (3), chronic alcohol drinking (4), chronic kidney disease (5), and asthma (6).
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