Interleukin-1 alpha (IL-l?) is a member of the IL-1 superfamily containing IL-l?, IL-l?, and IL- 1Ra receptor antagonist. IL-l? is known as hematopoietin (IL-1F1) and IL-l? as catabolin (IL- 1F2). IL-l? and IL-l? are corresponding to two different isoelectric forms, acidic pI 5 and neutral pI 7, respectivelybeta. IL-l? has a molecular mass of 17 kDa and consist of 159 amino acids having 26-33% homology with IL-l? (1-6). They are produced mainly by macrophages and monocytes, processed and released during apoptosis, and bind with high affinity to specific receptors on target cells. While only the mature form of IL-l? has biological activity, both the pro and mature forms of IL-l? are active (7). IL-l? and -? are pro-inflammatory cytokine involved in immune responses, inflammatory reactions, and hematopoiesis (8-9). IL-l? is an epidemal cytokine that is constitutively produced by epithelial cells and plays important role in maintenance of skin barrier function (10). The polymorphism of increased IL-1 production in patients is associated with rheumatoid arthritis, coagulation, solid tumors, leukemias, Alzheimer
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