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Human upcyte® Hepatocytes
Medicyte GmbH

Supplier:

Medicyte GmbH

Cat no: UH0-C00-0c04

Human upcyte® Hepatocytes

Medicyte's upcyte® Hepatocytes are genetically engineered human cell strains, derived from single donor primary cells.

Benefits of upcyte® Hepatocytes at a glance:
• Batch sizes up to 2000 vials per donor
• >90 % plateability
• Different donors available
upcyte® Hepatocytes have been tested at each expansion state for:
• Cell morphology
• Viable recovery (~70% of the original viable cells frozen are recovered after thawing)
• >90 % plateability
• Markers: CK8+, CK18+; HSA+, AAT+, AFP-
• Capacity for glycogen storage (PAS staining)
• Inducible CYP activities
upcyte® Hepatocytes have been tested at later expansion stages:
• Urea secretion (basal and stimulated)

We have demonstrated that upcyte® Hepatocytes show similar sensitivity to hepatotoxins to primary cells. Using upcyte® Hepatocytes during screening phases can exclude compounds at an early stage, which means toxic compounds do not reach animal testing stages. Save lives and money!

Tested Applications:
• CYP Induction
• CYP Inhibition
• Genotoxicity
• Basal toxicity
• Cell-specific toxicity (e. g. compounds requiring drug transporters or metabolism)
• HCV infection and virus replication

In addition to our cryopreserved upcyte® Hepatocytes we offer plated human upcyte® Hepatocytes in 6-well plates, 12-well plates, 24-well plates, 48-well plates and 96-well plates.

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SPECIFICATIONS

Catalog Number

UH0-C00-0c04

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