Human Zinc finger BED domain-containing protein 3 (ZBED3) ELISA Kit

Cat no: KTE60005

Supplier: Abbkine Scientific Co.Ltd.

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Zbed3 contains a PPPPSPT motif, which is crucial to its binding to Axin. The Ser and Thr residues in the motif appear to be also phosphorylated by glycogen synthase kinase 3? (GSK3?) and the CKI family kinases, as GSK3? and CKI? could enhance the interaction of Zbed3 with Axin. Expressing Zbed3, but not these mutants, led to inhibition of GSK3?-mediated ?-catenin phosphorylation, cytoplasmic ?-catenin accumulation, and activation of lymphoid enhancer binding factor-1-dependent reporter gene transcription. Furthermore, knockdown of Zbed3 with RNA interference attenuated Wnt-induced ?-catenin accumulation, lymphoid enhancer binding factor-1-dependent luciferase reporter activity, and the Wnt target gene expression. Zbed3 is a novel Axin-binding protein that is involved in Wnt/?-catenin signaling modulation.

Catalogue number:	KTE60005
Reactivities:	Human
Applications:	ELISA
Size:	48T, 96T, 96T5, 96T50
Accession:	Q96IU2
Gene:	84327
Additional info:	Human Zinc finger BED domain-containing protein 3 (ZBED3) ELISA Kit has high sensitivity and excellent specificity for detection of Human ZBED3. No significant cross-reactivity or interference between Human ZBED3 and analogues was observed.

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Human Zinc finger BED domain-containing protein 3 (ZBED3) ELISA Kit

Cat no: KTE60005

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