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IDO, Recombinant, Mouse (His) (Indoleamine 2,3-dioxygenase, INDO)

Cat no: 044896

IDO, Recombinant, Mouse (His) (Indoleamine 2,3-dioxygenase, INDO)

IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.\n\nBiological Activity:\nSpecific Activity: >100,000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.\n\nSequence:\nMouse IDO (aa 1-407) is fused at the C-terminus to a His-tag.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nWorking aliquots are stable for up to 3 months when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044896

Size

50ug

Form

0.2um-filtered solution in 50mM TRIS-Cl, pH 7.4, 1mM EDTA.

Purity

>90% (SDS-PAGE)

Alternative Names

Indoleamine 2,3-dioxygenase, INDO

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