IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
Biological Activity:
Specific Activity: >100,000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.
Sequence:
Mouse IDO (aa 1-407) is fused at the C-terminus to a His-tag.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Working aliquots are stable for up to 3 months when stored at -20 degrees C.
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