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IGFBP2, Recombinant, Human (Insulin-like Growth Factor-binding Protein 2, IBP-2, IGF-binding Protein 2, IGFBP-2, BP2, IBP2)

Cat no: 149663

IGFBP2, Recombinant, Human (Insulin-like Growth Factor-binding Protein 2, IBP-2, IGF-binding Protein 2, IGFBP-2, BP2, IBP2)

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5kD protein consisting of 289aa including the IGF-BP domain and thyroglobulin type-I domain.\n\nSource:\nRecombinant protein corresponding to human IGF-BP2.\n\nBiological Activity:\nDetermined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.\n\nEndotoxin:\n<0.1ng/ug (1EU/ug)\n\nAA Sequence:\nEVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

149663

Size

5ug

Form

Supplied as a lyophilized powder.

Purity

~98% (SDS-PAGE and HPLC)

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