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IGFBP5 Polyclonal Antibody

Cat no: 10008207

IGFBP5 Polyclonal Antibody

Antigen: human IGFBP5 amino acids 192-206 . Host: rabbit . Cross Reactivity: (+) mouse and rat IGFBP5 . Application(s): WB . IGFBP5 is a secreted protein that binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis.

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SPECIFICATIONS

Catalog Number

10008207

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human IGFBP5 amino acids 192-206 (CRRHMEASLQELKAS)

Storage Temp

-20

Shipping Temp

-20

Additional Info

Insulin-like growth factor binding protein 5 (IGFBP5) is a secreted protein that binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis. IGFBP5 also displays IGF-1 independent transactivational activity in the nucleus. Some tissues and cell types with higher levels of this protein include kidney, heart, placenta, and skeletal cells. Expression has also been reported in a variety of cancers, including mammary gland and neuroblastoma. IGFBP5 (272 amino acids) has a calculated molecular weight of 30.6 kDa. Reported glycosylation and phosphorylation sites may explain the band migration to 33 kDa.

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