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Products IGFBP5 Polyclonal Antibody
| Catalogue number: | 10008207 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human IGFBP5 amino acids 192-206 (CRRHMEASLQELKAS) |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Insulin-like growth factor binding protein 5 (IGFBP5) is a secreted protein that binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis. IGFBP5 also displays IGF-1 independent transactivational activity in the nucleus. Some tissues and cell types with higher levels of this protein include kidney, heart, placenta, and skeletal cells. Expression has also been reported in a variety of cancers, including mammary gland and neuroblastoma. IGFBP5 (272 amino acids) has a calculated molecular weight of 30.6 kDa. Reported glycosylation and phosphorylation sites may explain the band migration to 33 kDa. |
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