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Products IkB(alpha) Monoclonal Antibody - biotin (Clone 6A920)
| Catalogue number: | 13922 |
| Hosts: | Mouse |
| Applications: | ELISA |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | recombinant protein corresponding to human IkBa amino acids 32-291 |
| P type: | Antibodies|NF-.kappa.B|Intracellular Signaling |
| Isotype: | IgG1k |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | NF-kB is silenced in the cytoplasm by an inhibitory protein IkB. Synthesis of IkB(alpha) is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/(alpha), IKK2/(beta), and IKK3/(gamma). External stimuli such as tumor necrosis factor or other cytokines induce phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimers subsequently translocate to the nucleus and activate target genes. Six members of the IkB family have been identified. One of the first genes induced following NF-kB activation is IkB(alpha). This product is a biotinylated form of IkBa Monoclonal Antibody (Clone 6A920) (Item No. 13918). |
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