IkB(alpha) (Phospho-Ser32/36) Monoclonal Antibody - biotin (Clone 39A1413)

Antigen: synthetic peptide containing phosphorylated serines corresponding to human IkB(alpha) amino acids 32 and 36 . Host: mouse, clone 39A1413 . Isotype: IgG1k . Cross Reactivity: (+) bovine, canine, human, mouse, porcine, and rat IkB(alpha) . Application(s): ELISA . The product is a biotinylated form of IkB(alpha) (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413) (Item No. 13923).

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SPECIFICATIONS

Catalog Number

13924

Applications

ELISA

Hosts

Mouse

Form

1 ea

P Type

Antibodies|NF-.kappa.B|Intracellular Signaling

Weight

0

Antigen

synthetic peptide containing phosphorylated serines corresponding to human IkB(alpha) amino acids 32 and 36

Isotype

IgG1k

Storage Temp

-20

Shipping Temp

-20

Additional Info

NF-kB is silenced in the cytoplasm by an inhibitory protein IkB. Synthesis of IkB(alpha) is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/(alpha), IKK2/(beta), and IKK3/(gamma). External stimuli such as tumor necrosis factor or other cytokines initiates a signal transduction cascade that leads to activation of the IkB-kinase complex that specifically phosphorylates IkBa on serine32 and serine36. Phosphorylation of these sites leads to ubiquitination of IkB(alpha) and susequent degradation by the 26 S-proteasome. Degradation of IkB(alpha) results in unmasking of the nuclear localization signal of NF-kB dimers, which subsequently translocate to the nucleus and activate target genes. Six members of the IkB family members have been identified. One of the first genes induced following NF-kB activation is IkB(alpha). The product is a biotinylated form of IkB(alpha) (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413) (Item No. 13923).