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Products IkB(alpha) (Phospho-Ser32/36) Monoclonal Antibody - biotin (Clone 39A1413)
| Catalogue number: | 13924 |
| Hosts: | Mouse |
| Applications: | ELISA |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide containing phosphorylated serines corresponding to human IkB(alpha) amino acids 32 and 36 |
| P type: | Antibodies|NF-.kappa.B|Intracellular Signaling |
| Isotype: | IgG1k |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | NF-kB is silenced in the cytoplasm by an inhibitory protein IkB. Synthesis of IkB(alpha) is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/(alpha), IKK2/(beta), and IKK3/(gamma). External stimuli such as tumor necrosis factor or other cytokines initiates a signal transduction cascade that leads to activation of the IkB-kinase complex that specifically phosphorylates IkBa on serine32 and serine36. Phosphorylation of these sites leads to ubiquitination of IkB(alpha) and susequent degradation by the 26 S-proteasome. Degradation of IkB(alpha) results in unmasking of the nuclear localization signal of NF-kB dimers, which subsequently translocate to the nucleus and activate target genes. Six members of the IkB family members have been identified. One of the first genes induced following NF-kB activation is IkB(alpha). The product is a biotinylated form of IkB(alpha) (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413) (Item No. 13923). |
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