Quick Search
Products IkB(alpha) (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413)
| Catalogue number: | 13923 |
| Hosts: | Mouse |
| Applications: | Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide containing phosphorylated serine residues corresponding to human IkB(alpha) amino acids 32 and 36 |
| P type: | Antibodies|NF-.kappa.B|Intracellular Signaling |
| Isotype: | IgG1k |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | NF-kB is silenced in the cytoplasm by an inhibitory protein IkB. Synthesis of IkB(alpha) is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/(alpha), IKK2/(beta), and IKK3/(gamma). External stimuli such as tumor necrosis factor or other cytokines initiates a signal transduction cascade that leads to activation of the IkB-kinase complex that specifically phosphorylates IkBa on serine32 and serine36. Phosphorylation of these sites leads to ubiquitination of IkB(alpha) and subsequent degradation by the 26S proteasome. Degradation of IkB(alpha) results in unmasking of the nuclear localization signal of NF-kB dimers, which subsequently translocate to the nucleus and activate target genes. Six members of the IkB family members have been identified. one of the first genes induced following NF-kB activation is IkB(alpha). |
Get the Best Promotions
